Psilocybin tends to enter the brain quickly and if it is ingested orally, the effects peak about 60 to 90 minutes after taking it, experts said. Most of the time, experts say the active effects of psilocybin last about four to eight hours, and the drug is completely gone from your body after 24 hours. “We haven’t had evidence of anyone having a prolonged reaction to psilocybin,” Barrett said, referring to the acute effects of the drug….”

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